Ginkgo series
Ginkgo, a tree native to China, stands as one of the world's oldest tree species, dating back to the Carboniferous period, around 230,000 years ago. With an average lifespan ranging from 2000 to 4000 years, ginkgo showcases remarkable tenacity and vitality.
Having served as a traditional Chinese medical material, ginkgo has been cultivated and utilized for thousands of years, highlighting its enduring importance in traditional practices.
-
In 2011, we initiated the trial production of ginkgo biloba extract in our first workshop. Despite the industry's chaotic landscape at that time, we remained steadfast in our commitment to manufacturing authentic products.
-
In 2015, the former CFDA (now the State Administration for Market Regulation) conducted an extensive investigation of 90 ginkgo biloba extract manufacturers nationwide. Delekang stood out as one of the few companies whose products were all certified as qualified. Our unwavering dedication to quality was recognized, and we secured a strong position in the market.
-
In 2016, Delekang's ginkgo biloba extract was approved as an API (Active Pharmaceutical Ingredient) by the former FDA of Jiangsu province. Through collaborations with various drug companies, we continuously optimized the quality of our ginkgo biloba extract, ensuring its stability in various dosage forms.
-
By 2019, we achieved a significant breakthrough in quality. Ginkgolic acid was controlled below 1ppm, and ginkgo toxin below 50 ppm, meeting the EU regulation on maximum pesticide residue levels (EC No 396/2005).
-
In the same year, during the ginkgo biloba extraction process, we discovered shikimic acid, offering a cost-effective solution that reduced its market price. Building on this discovery, we achieved mass production of shikimic acid in 2020, further enhancing the accessibility of this valuable product.
The data speaks for itself. Over the past decade, our technical progress has enabled us to make high-quality products more affordable and accessible to a wider audience.
Ginkgo biloba extract
CAS number：90045-36-6
HS code：13021940.00
Summary
In the 1960s, the Dr. Willmar Schwabe Group developed standardized Ginkgo biloba extract EGb 761, known for promoting vasodilation and enhancing blood flow. This extract is used to treat various conditions, including memory loss and tinnitus[1]. In 2014, the assessment report by EMA (European Medicines Agency) acknowledged the therapeutic benefits of ginkgo biloba extract in improving cognitive impairment associated with aging and enhancing the quality of life in mild dementia[2]. Additionally, Ginkgo biloba extract is widely utilized as a dietary supplement in the United States[3]. In China, the main functions of ginkgo biloba extract preparations are:
Enhancing blood circulation to alleviate obstruction in collaterals, this treatment is suitable for patients experiencing chest blockage, heartache, stroke, hemiplegia, stiff tongue due to blood stasis and collateral blockage, as well as stable angina pectoris and cerebral infarction associated with the mentioned syndromes.[4]
Delekang's Ginkgo biloba extract has received approval from the State Administration for Market Regulation (previously known as the Food and Drug Administration) and is authorized for use as an API (Active Pharmaceutical Ingredient) in the production of diverse drug preparations. Additionally, we have obtained the "Food Production License", allowing us to manufacture Ginkgo biloba extract for dietary supplements.
Our Advantages
-
Ginkgo biloba extract is a commonly used ingredient produced by many plant extract manufacturers. However, achieving good, let alone excellent, quality is a challenge that only a few can accomplish. Over the past decade, we have continuously elevated the quality of our ginkgo biloba extract through the following measures:
-
We have established long-term partnerships with ginkgo leaf suppliers, enabling us to collect and analyze extensive quality data from various regions. This helps us identify suitable raw materials for standardized products with consistent quality.
-
Our production process adheres to the standards set by Chinese Pharmacopoeia, U.S. Pharmacopoeia, and European Pharmacopoeia.
-
We comply with the EU regulations on maximum pesticide residue levels (EC No 396/2005).
-
Our extract contains ginkgolic acid below 1ppm and ginkgotoxin below 50ppm.
-
Our production line has received approval from China FDA.
-
Our extract is compatible with most oral dosage forms, ensuring ease of use for various pharmaceutical applications.
-
-
In addition to ensuring high quality, Delekang strives to make its products more affordable. As a specialized manufacturer, we have the following advantages:
-
We have developed advanced technology that allows us to fully utilize raw materials, reducing the cost of production. Extracted ginkgo leaves and waste materials can be repurposed to extract sodium copper chlorophyllin and shikimic acid, while used leaves serve as fuel, providing renewable energy for the production line.
-
Our scale of operation helps dilute fixed costs per unit, including investments in research and development, equipment, and facilities, leading to more cost-effective production.
-
Unlike generic extraction equipment, our specialized production line designed for ginkgo biloba enables more effective quality control and cost reduction during production.
-
Specifications
| Items | CP | USP | EP | In-house |
|---|---|---|---|---|
| Flavonol glycosides | ≥24.0% | 22.0-27.0% | 22.0-27.0% | 22.0-27.0% |
| Terpene lactones | ≥6.0% | 5.4-12.0% | 5.4-6.6% | 5.4-12.0% |
| Bilobalide | / | 2.6-5.8% | 2.6-3.2% | 2.6-5.8% |
| Ginkgolide | / | 2.8-6.2% | 2.8-3.4% | 2.8-6.2% |
| Quercetin/kaempferol ratio | 0.8-1.2 | / | / | 0.8-1.2 |
| Isorhamnetin/Quercetin ratio | ≥0.15 | / | / | ≥0.15 |
| Ginkgolic acid | ≤5mg/kg | ≤5mg/kg | ≤5mg/ kg | ≤1mg/kg |
| Free quercetin | ≤10mg/g | ≤5mg/g | / | ≤10mg/g |
| Free kaempferol | ≤10mg/g | / | / | ≤10mg/g |
| Free isorhamnetin | ≤4mg/g | / | / | ≤4mg/g |
| Rutin | / | ≤4.0% | / | / |
| Pesticide residues | / | USP<561> | EC396/2005 | / |
| Loss on drying | ≤5.0% | ≤5.0% | ≤5.0% | ≤4.0% |
| Residue on ignition | ≤0.8% | / | / | ≤0.8% |
| Heavy metals | ≤20m g/kg | / | / | ≤15m g/kg |
| HPLC Fingerprint | ≥0.90 | / | / | ≥0.90 |
Package and storage
25 kg/drums; protected from light; stored in airtight and dry condition
Shikimic acid
CAS number: 138-59-0
HS Custom code: 2918190090
Molecular mass: 174.15
Structure
Specification
| Items | sepcifications |
|---|---|
| Specific rotation[α]D 25°C/° | -175~-184 |
| Content | ≧98.0% |
| Heavy metals | ≦20ppm |
| Residue on ignition | ≤0.8 % |
| Loss on drying | ≤1.0% |
| Solubility | 18% m/v (soluble in water) |
| Appearance | white to light yellow fine powder |
| Plant origin | Ginkgo biloba L. |
Packaging and storage
25kg/drum Protect from light and stored in airtight and dry condition
Quinic acid
CAS编号：77-95-2
Chemical formula：C7H12O6
Molecular mass：192.17
Structure
Specification
| Items | sepcifications |
|---|---|
| Specific rotation[α]D 25°C/° | -42~-44 |
| Content | ≧98.0% |
| Heavy metals | ≦20ppm |
| Residue on ignition | ≤0.8 % |
| Loss on drying | ≤1.0% |
| Appearance | white to light yellow crystalline powder |
| Plant origin | Ginkgo biloba L. |
Packaging and storage
25kg/drum Protect from light and stored in airtight and dry condition
References
- EGb 761: ginkgo biloba extract, Ginkor. Drugs R D. 2003;4(3):188-93. doi: 10.2165/00126839-200304030-00009. PMID: 12757407.
- Committee on Herbal Medicinal Products. "Assessment report on Ginkgo biloba L., folium" (PDF). European Medicines Agency.
- Z. Pang, F. Pan, and S. He.The Journal of Alternative and Complementary Medicine.Sep 1996.359-363.
- Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China[M].Ginkgo Leaves Extract, 2020,(1):1614.