Rice bran series

Summary

In the 1890s, a Dutch military physician, Christiaan Eijkman and his assistant discovered that polished “white rice” could cause leg weakness on chickens. It was later proved that the Vitamin B1 removed during the polishing (i.e. the rice bran) was the cause of sick chickens^[1]. Subsequently, the micronutrients rich in rice bran were continuously discovered, such as oryzanol, sitosterol, vitamin E, squalene, etc.^[2]

Since its establishment in 1994, Delekang has been dedicated to research and manufacture of rice bran series products. We have successively developed oryzanol, ferulic acid, rice bran sterol and phytosterol, continuously exploiting the value of rice bran.

History of rice bran series

• In July 1995, gamma oryzanol was launched in the market.

• In 2003, Delekang developed the rice bran oil of first-class in national standard.

• In 2005, ferulic acid was introduced.

Rice bran oil

Introduction

In the perspective of nutrition, oils and fats is the carrier of fat-soluble Vitamin A, D and E, and also an important part of cell walls and other biological structures. In cooking, oils and fats also affect the flavor of food. ^[3]

Vitamin E, including our tocopherols and four tocotrienols ^[4], is a fat-soluble antioxidant that protects cell membrane from reactive oxygen species (ROS). ^[5]

Compared with tocopherols, tocotrienols have stronger anti-oxidant property^[6], which are naturally derived from plant oil, especially rice bran oil.^[7]

The content of Vitamin E in plant oils（mg/kg)^[7]

Specification

Based on the national standard GB/T 19112-2003

Packaging

Storage

Store in light-tight, airtight and dry condition

Gamma Oryzanol

CAS number: 11042-64-1

HS code: 29189900.90

National standard code: WS1-47(B)-89-2016

Introduction

Gamma oryzanol is a lipid composite mainly derived from rice bran. It is used to improve climacteric syndrome, anxiety, insomnia in Japan,^[8] while in China, it is used for dysautonomia premenstrual syndrome and climacteric syndrome. ^[9]

Structure

β-sitosteryl ferulate (5-10%)

Campesteryl ferulate (10-15%)

Cycloartenyl Ferulate (25-30%)

24-methylene-cycloartanyl ferulate (35-40%)

Specification

Packaging

20 kg/drum

Storage

Store in light-tight, airtight and dry condition

Ferulic acid

CAS number: 537-98-4

HS code: 29189900.90

Other name: (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid

Chemical formula C10H10O4

Molecular mass 194.184

Introduction

Ferulic acid is a very common component in natural plants and usually used as a raw material for spices. It mainly exists in the cell wall. Its tronger antioxidant property can protect cell, which make ferulic acid applicable as antioxidant and photostage inhabitation in cosmetics ^[10]. Ferulic acid also presents in some herbal medicines, such as female ginseng, Cimicifuga foetida and Ligusticum wallichii. ^[11]

Structure

Specification

Packaging

20 kg/drum

Storage

Store in light-tight, airtight and dry condition

Phytosterol

CAS number: 83-46-5

HS number: 29061990.90

Introduction

Sterols are the major trace substance in fat.

Cholesterol is a type of sterols, the main sterols in animal’s fat. There are two types of sterols in human blood: high-density lipoprotein (HDL)cholesterol and low-density lipoprotein (LDL) cholesterol. Excessive accumulation of LDL cholesterol in the serum can lead to blockage of arteries and heart disease.

Acceding to the EFSA

Moderate intake of phytosterol can lower blood cholesterol level and reduce the risk of coronary heart disease. ^[12]

The U.S. Food and Drug Administration (FDA) allows food labels to be noted：

Phytosterol can reduce the risk of coronary heart disease. ^[13]

Health Canada also allows it to be shown on food labels that plant sterol can help reduce cholesterol level. ^[14]

Although phytosterol has good stability, it can cause oxidation when it is exposed to high temperatures or the air. Eating oxidizing phytosterols can lead to inflammation, unstable hormone levels, carcinogenicity and other health problems.

Application

Industrial grade: it can be used as the starting material for steroid drugs

Food grade: it can be used as food additives, health care raw materials

Specification

Specification

Packaging

20 kg/drum

Storage

Store in airtight, light-tight and dry condition

Rice bran sterol

CAS number: 83-46-5

HS custom number: 2906199090

National standard code： WS-10001-(HD-0908)-2002

Introduction

Sterol, also known as Rice Bran Sterol Tablets in China, is used for bleeding gums, periodontal abscesses and other conditions caused by periodontal disease.

Specification

Packaging

25 kg/drum

Storage condition

Prevented from light and stored in airtight and dry condition

Reference

1. "The Nobel Prize and the Discovery of Vitamins". www.nobelprize.org.
2. Barron, Jon (21 September 2010). "Black Rice Bran, the Next Superfood?". Baseline of Health Foundation.
3. S. M. Ghazani; A. G. Marangoni (4 January 2016). "Healthy Fats and Oils". Encyclopedia of Food Grains, Vol: 2-4, 257-267.
4. "Vitamin E". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. 1 October 2015.
5. "Vitamin E". Office of Dietary Supplements, US National Institutes of Health. 12 July 2019.
6. Serbinova E, Kagan V, Han D, Packer L (1991). "Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol". Free Radical Biology & Medicine. 10 (5): 263–75.
7. 吴轲, 孙涵潇,祝 捷,蔡美琴.中国油脂[J].常见食用植物油中维生素 E 异构体含量调查研究,2019,(44-10):95-99.
8. Fuji M, Butler JP, et al. Gamma-oryzanol for behavioural and psychological symptoms of dementia. Psychogeriatrics. 2018;18(2):151-152.
9. 中华人民共和国卫生部药典委员会.中华人民共和国卫生部药品标准化学药品及制剂[M].谷维素, 1989,(1):H1-55.
10. Zduńska K, Dana A, Kolodziejczak A, Rotsztejn H: Antioxidant Properties of Ferulic Acid and Its Possible Application. Skin Pharmacol Physiol 2018;31:332-336.
11. Sakai, S.; Kawamata, H.; Kogure, T.; Mantani, N.; Terasawa, K.; Umatake, M.; Ochiai, H. (1999). "Inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells". Mediators of Inflammation. 8(3): 173–175.
12. European Food Safety Authority. Scientific Opinion of the Panel on Dietetic Products Nutrition and Allergies on a request from Unilever PLC/NV on Plant Sterols and lower/reduced blood cholesterol, reduced the risk of (coronary) heart disease. The EFSA Journal (2008) 781, 1–12.
13. U.S. Food & Drug Administration. Health claims: plant sterol/stanol esters and risk of coronary heart disease (CHD). 21 C.F.R. §101.83 (2017, April 1).
14. Health Canada. (2010, May 26). Plant Sterols and Blood Cholesterol Lowering.

Ginkgo series

Ginkgo, a tree native to China, stands as one of the world's oldest tree species, dating back to the Carboniferous period, around 230,000 years ago. With an average lifespan ranging from 2000 to 4000 years, ginkgo showcases remarkable tenacity and vitality.

Having served as a traditional Chinese medical material, ginkgo has been cultivated and utilized for thousands of years, highlighting its enduring importance in traditional practices.

• In 2011, we initiated the trial production of ginkgo biloba extract in our first workshop. Despite the industry's chaotic landscape at that time, we remained steadfast in our commitment to manufacturing authentic products.

• In 2015, the former CFDA (now the State Administration for Market Regulation) conducted an extensive investigation of 90 ginkgo biloba extract manufacturers nationwide. Delekang stood out as one of the few companies whose products were all certified as qualified. Our unwavering dedication to quality was recognized, and we secured a strong position in the market.

• In 2016, Delekang's ginkgo biloba extract was approved as an API (Active Pharmaceutical Ingredient) by the former FDA of Jiangsu province. Through collaborations with various drug companies, we continuously optimized the quality of our ginkgo biloba extract, ensuring its stability in various dosage forms.

• By 2019, we achieved a significant breakthrough in quality. Ginkgolic acid was controlled below 1ppm, and ginkgo toxin below 50 ppm, meeting the EU regulation on maximum pesticide residue levels (EC No 396/2005).

• In the same year, during the ginkgo biloba extraction process, we discovered shikimic acid, offering a cost-effective solution that reduced its market price. Building on this discovery, we achieved mass production of shikimic acid in 2020, further enhancing the accessibility of this valuable product.

The data speaks for itself. Over the past decade, our technical progress has enabled us to make high-quality products more affordable and accessible to a wider audience.

Ginkgo biloba extract

CAS number：90045-36-6

HS code：13021940.00

Summary

In the 1960s, the Dr. Willmar Schwabe Group developed standardized Ginkgo biloba extract EGb 761, known for promoting vasodilation and enhancing blood flow. This extract is used to treat various conditions, including memory loss and tinnitus^[1]. In 2014, the assessment report by EMA (European Medicines Agency) acknowledged the therapeutic benefits of ginkgo biloba extract in improving cognitive impairment associated with aging and enhancing the quality of life in mild dementia^[2]. Additionally, Ginkgo biloba extract is widely utilized as a dietary supplement in the United States^[3]. In China, the main functions of ginkgo biloba extract preparations are:

Enhancing blood circulation to alleviate obstruction in collaterals, this treatment is suitable for patients experiencing chest blockage, heartache, stroke, hemiplegia, stiff tongue due to blood stasis and collateral blockage, as well as stable angina pectoris and cerebral infarction associated with the mentioned syndromes.^[4]

Delekang's Ginkgo biloba extract has received approval from the State Administration for Market Regulation (previously known as the Food and Drug Administration) and is authorized for use as an API (Active Pharmaceutical Ingredient) in the production of diverse drug preparations. Additionally, we have obtained the "Food Production License", allowing us to manufacture Ginkgo biloba extract for dietary supplements.

Our Advantages

1. Ginkgo biloba extract is a commonly used ingredient produced by many plant extract manufacturers. However, achieving good, let alone excellent, quality is a challenge that only a few can accomplish. Over the past decade, we have continuously elevated the quality of our ginkgo biloba extract through the following measures:

   • We have established long-term partnerships with ginkgo leaf suppliers, enabling us to collect and analyze extensive quality data from various regions. This helps us identify suitable raw materials for standardized products with consistent quality.

   • Our production process adheres to the standards set by Chinese Pharmacopoeia, U.S. Pharmacopoeia, and European Pharmacopoeia.

   • We comply with the EU regulations on maximum pesticide residue levels (EC No 396/2005).

   • Our extract contains ginkgolic acid below 1ppm and ginkgotoxin below 50ppm.

   • Our production line has received approval from China FDA.

   • Our extract is compatible with most oral dosage forms, ensuring ease of use for various pharmaceutical applications.

2. In addition to ensuring high quality, Delekang strives to make its products more affordable. As a specialized manufacturer, we have the following advantages:

   • We have developed advanced technology that allows us to fully utilize raw materials, reducing the cost of production. Extracted ginkgo leaves and waste materials can be repurposed to extract sodium copper chlorophyllin and shikimic acid, while used leaves serve as fuel, providing renewable energy for the production line.

   • Our scale of operation helps dilute fixed costs per unit, including investments in research and development, equipment, and facilities, leading to more cost-effective production.

   • Unlike generic extraction equipment, our specialized production line designed for ginkgo biloba enables more effective quality control and cost reduction during production.

Specifications

Package and storage

25 kg/drums; protected from light; stored in airtight and dry condition

Shikimic acid

CAS number: 138-59-0

HS Custom code: 2918190090

Molecular mass: 174.15

Structure

Specification

Packaging and storage

25kg/drum Protect from light and stored in airtight and dry condition

Quinic acid

CAS编号：77-95-2

Chemical formula：C₇H₁₂O₆

Molecular mass：192.17

Structure

Specification

Packaging and storage

25kg/drum Protect from light and stored in airtight and dry condition

References

1. EGb 761: ginkgo biloba extract, Ginkor. Drugs R D. 2003;4(3):188-93. doi: 10.2165/00126839-200304030-00009. PMID: 12757407.
2. Committee on Herbal Medicinal Products. "Assessment report on Ginkgo biloba L., folium" (PDF). European Medicines Agency.
3. Z. Pang, F. Pan, and S. He.The Journal of Alternative and Complementary Medicine.Sep 1996.359-363.
4. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China[M].Ginkgo Leaves Extract, 2020,(1):1614.

Green Tea series

Green tea extract

CAS number: 84650-60-2

HS customs number:

Appearance

Tea polyphenols, freely soluble in water, ethanol, ethyl acetate and slightly soluble in oils, are white to brown powdery solids or crystals with astringent taste. They are stable under hot or acidic condition in the range of PH 2~7. They are slightly hygroscopic, the PH of their aqueous solution is 3~4. Tea polyphenols are easy to be oxidized and become brown under alkaline condition. Green-black compounds are formed when they meet iron ions.

Specification

Packaging

25kg/drum

Storage condition

Store in dark, airtight and dry place.

L-Theanine

CAS number: 3081-61-6

HS customs number:

Structure

Quality specification

Package

20kg/drum

Storage condition

Protect from light and stored in airtight and dry condition